Workshop report on Hodgkin's disease and related diseases ('grey zone' lymphoma)

T Rudiger*, ES Jaffe, G Delsol, C deWolf-Peeters, RD Gascoyne, A Georgii, NL Harris, ME Kadin, KA MacLennan, S Poppema, H Stein, LE Weiss, HK Muller-Hermelink

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    26 Citaten (Scopus)


    Despite advances in immunohistochemistry and molecular biology, the distinction between classical Hodgkin's lymphoma and related diseases such as nodular lymphocyte-predominant Hodgkin's disease, T-cell rich large B-cell lymphoma or anaplastic large cell lymphoma has remained difficult in rare cases. Lack of clear-cut diagnostic criteria represents a problem for both the pathologist and the clinician.

    To delineate this 'grey zone' between classical Hodgkin's lymphoma and non-Hodgkin's lymphoma (NHL) and to develop criteria for classification of such cases, 12 expert hematopathologists each submitted one to five borderline cases to a workshop. Cases were reviewed and classified at a multiheaded microscope and criteria were established for the diagnosis of questionable cases. Well established entities such as classical Hodgkin's lymphoma? anaplastic large-cell lymphoma and TCRBCL were defined more strictly and cases with unusual morphology or antigen expression could be identified. A distinctive subset of cases representing mediastinal large B-cell lymphomas with features of Hodgkin's lymphoma was identified.

    Originele taal-2English
    Pagina's (van-tot)31-38
    Aantal pagina's8
    TijdschriftAnnals of Oncology
    StatusPublished - 1998
    Evenement4th Symposium on Hodgkins Disease - , Germany
    Duur: 28-mrt-19981-apr-1998

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