Workshop report on Hodgkin's disease and related diseases ('grey zone' lymphoma)

T Rudiger*, ES Jaffe, G Delsol, C deWolf-Peeters, RD Gascoyne, A Georgii, NL Harris, ME Kadin, KA MacLennan, S Poppema, H Stein, LE Weiss, HK Muller-Hermelink

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    26 Citaten (Scopus)

    Samenvatting

    Despite advances in immunohistochemistry and molecular biology, the distinction between classical Hodgkin's lymphoma and related diseases such as nodular lymphocyte-predominant Hodgkin's disease, T-cell rich large B-cell lymphoma or anaplastic large cell lymphoma has remained difficult in rare cases. Lack of clear-cut diagnostic criteria represents a problem for both the pathologist and the clinician.

    To delineate this 'grey zone' between classical Hodgkin's lymphoma and non-Hodgkin's lymphoma (NHL) and to develop criteria for classification of such cases, 12 expert hematopathologists each submitted one to five borderline cases to a workshop. Cases were reviewed and classified at a multiheaded microscope and criteria were established for the diagnosis of questionable cases. Well established entities such as classical Hodgkin's lymphoma? anaplastic large-cell lymphoma and TCRBCL were defined more strictly and cases with unusual morphology or antigen expression could be identified. A distinctive subset of cases representing mediastinal large B-cell lymphomas with features of Hodgkin's lymphoma was identified.

    Originele taal-2English
    Pagina's (van-tot)31-38
    Aantal pagina's8
    TijdschriftAnnals of Oncology
    Volume9
    StatusPublished - 1998
    Evenement4th Symposium on Hodgkins Disease - , Germany
    Duur: 28-mrt-19981-apr-1998

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